PoroViscoElastic model to describe hydrogels’ behavior – Model implementation in COMSOL

PoroViscoElastic model to describe hydrogels’ behavior – Model implementation in COMSOL

In the following a 15 minutes video guide to show a very basic implementation in COMSOL Multiphysics of the poroviscoelastic model proposed in “Caccavo D. & Lamberti G. (2017). PoroViscoElastic model to describe hydrogels’ behavior. Materials Science and Engineering: C 76: 102-113, DOI: 10.1016/j.msec.2017.02.155 ”. Aim of this guide is to provide an initial aid […]

New Trends in Gene Therapy: Multidisciplinary Approaches to siRNAs Controlled Delivery

New Trends in Gene Therapy: Multidisciplinary Approaches to siRNAs Controlled Delivery

Recently the TPP group, within the frame of project PRIN 2010-11, has participated to the production of a special issue entitled: “New Trends in Gene Therapy: Multidisciplinary Approaches to siRNAs Controlled Delivery” published on Current Drug Delivery. In the following the Editorial: Nucleic acid based drugs (NABDs), powerful in principle, can be of great importance […]

Mathematical modeling of drug release from coated pellets

Mathematical modeling of drug release from coated pellets

The TPP research group, in collaboration with Chalmers and AstraZeneca, has recently published an article on the controlled drug release from pellets: CACCAVO, D., LAMBERTI, G., CAFARO, M. M., BARBA, A. A., KAZLAUSKE, J. & LARSSON, A. (in press). Mathematical modeling of the drug release from an ensemble of coated pellets. British Journal of Pharmacology, […]

Wivace 2016 – Bionam 2016

Wivace 2016 – Bionam 2016

From 4th to 7th October 2016, the two workshops Wivace 2016 (Workshop on Artificial Life and Evolutionary Computation) and Bionam 2016 (Workshop on bio-nanomaterials) will be held in Salerno. Download the final (flyer) Other info on the website www.wivace.org. The deadline for abstract submission is the 15th July 2016.

TPP Group at PBP 2016

TPP Group at PBP 2016

The TPP Group have been at the “10TH WORLD MEETING on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology” at Glasgow with two oral presentations. The works have displayed two pillars of the group’s research lines: drug release from hydrogel-based tablets (1), presentet by Eng. Diego Caccavo; in vitro and in silico pharmacokinetic models (2), presented by Dr. […]

ADME processes and in silico models

ADME processes and in silico models

Concerning the pharmacokinetic modeling, its main goal is the prediction of the blood and tissues drug concentrations. To reach this purpose, it has to be taken into account that the main processes subjected by a drug once assumed are: Absorption, Distribution, Metabolism, and Excretion, known as ‘ADME processes’. These processes determine the drug concentration evolution […]

Dissolution tests and in vitro models

Dissolution tests and in vitro models

The most widespread diffused administration route is the oral one, and dissolution and absorption are the main phenomena which take place when a drug is ingested. A drug could be administered in several forms, i.e. as tablets, capsules, granules, or aggregates, or even as powders. Independently on the dosage form, the first necessary step for […]

Liposomes-based delivery systems

Liposomes-based delivery systems

Liposomes-based delivery systems – Definition and Release Mechanism Liposomes are carrier systems suitable for the delivery of different active molecules; due to their unic features, they can be utilized in many fields of application such as pharmaceutical, medical, nutraceutical, cosmeceutical. In medical field liposomes are used for the controlled delivery of drugs in order to […]

Polymeric micro and nano particles: definition and benefits

Polymeric micro and nano particles: definition and benefits

Polymeric micro and nano particles: definition and benefits Several compounds were incorporated in micro or nano carriers by different techniques, in order to stabilize them, convert them into powders, mask undesired taste, provide modified release properties. These systems are then exploited for therapeutic purposes to transport the active principle in a controlled manner from the […]