In the following a 15 minutes video guide to show a very basic implementation in COMSOL Multiphysics of the poroviscoelastic model proposed in “Caccavo D. & Lamberti G. (2017). PoroViscoElastic model to describe hydrogels’ behavior. Materials Science and Engineering: C 76: 102-113, DOI: 10.1016/j.msec.2017.02.155 ”. Aim of this guide is to provide an initial aid […]
It has been published on-line (Volume 525, Issue 2, Pages 291-418 (20 June 2017)) the special issue of International Journal of Pharmaceutics devoted to the siRNAs delivery topic. siRNAs are promising new drug molecules. The special issue has been edited by GroupTPP, and our research is well presented on the volume. More info are here.
Recently the TPP group, within the frame of project PRIN 2010-11, has participated to the production of a special issue entitled: “New Trends in Gene Therapy: Multidisciplinary Approaches to siRNAs Controlled Delivery” published on Current Drug Delivery. In the following the Editorial: Nucleic acid based drugs (NABDs), powerful in principle, can be of great importance […]
The TPP research group, in collaboration with Chalmers and AstraZeneca, has recently published an article on the controlled drug release from pellets: CACCAVO, D., LAMBERTI, G., CAFARO, M. M., BARBA, A. A., KAZLAUSKE, J. & LARSSON, A. (in press). Mathematical modeling of the drug release from an ensemble of coated pellets. British Journal of Pharmacology, […]
From 4th to 7th October 2016, the two workshops Wivace 2016 (Workshop on Artificial Life and Evolutionary Computation) and Bionam 2016 (Workshop on bio-nanomaterials) will be held in Salerno. Download the final (flyer) Other info on the website www.wivace.org. The deadline for abstract submission is the 15th July 2016.
The TPP Group have been at the “10TH WORLD MEETING on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology” at Glasgow with two oral presentations. The works have displayed two pillars of the group’s research lines: drug release from hydrogel-based tablets (1), presentet by Eng. Diego Caccavo; in vitro and in silico pharmacokinetic models (2), presented by Dr. […]
Concerning the pharmacokinetic modeling, its main goal is the prediction of the blood and tissues drug concentrations. To reach this purpose, it has to be taken into account that the main processes subjected by a drug once assumed are: Absorption, Distribution, Metabolism, and Excretion, known as ‘ADME processes’. These processes determine the drug concentration evolution […]
The most widespread diffused administration route is the oral one, and dissolution and absorption are the main phenomena which take place when a drug is ingested. A drug could be administered in several forms, i.e. as tablets, capsules, granules, or aggregates, or even as powders. Independently on the dosage form, the first necessary step for […]
Liposomes-based delivery systems – Definition and Release Mechanism Liposomes are carrier systems suitable for the delivery of different active molecules; due to their unic features, they can be utilized in many fields of application such as pharmaceutical, medical, nutraceutical, cosmeceutical. In medical field liposomes are used for the controlled delivery of drugs in order to […]
Polymeric micro and nano particles: definition and benefits Several compounds were incorporated in micro or nano carriers by different techniques, in order to stabilize them, convert them into powders, mask undesired taste, provide modified release properties. These systems are then exploited for therapeutic purposes to transport the active principle in a controlled manner from the […]