PoroViscoElastic model to describe hydrogels’ behavior – Model implementation in COMSOL

PoroViscoElastic model to describe hydrogels’ behavior – Model implementation in COMSOL

In the following a 15 minutes video guide to show a very basic implementation in COMSOL Multiphysics of the poroviscoelastic model proposed in “Caccavo D. & Lamberti G. (2017). PoroViscoElastic model to describe hydrogels’ behavior. Materials Science and Engineering: C 76: 102-113, DOI: 10.1016/j.msec.2017.02.155 ”. Aim of this guide is to provide an initial aid […]

ADME processes and in silico models

ADME processes and in silico models

Concerning the pharmacokinetic modeling, its main goal is the prediction of the blood and tissues drug concentrations. To reach this purpose, it has to be taken into account that the main processes subjected by a drug once assumed are: Absorption, Distribution, Metabolism, and Excretion, known as ‘ADME processes’. These processes determine the drug concentration evolution […]

Dissolution tests and in vitro models

Dissolution tests and in vitro models

The most widespread diffused administration route is the oral one, and dissolution and absorption are the main phenomena which take place when a drug is ingested. A drug could be administered in several forms, i.e. as tablets, capsules, granules, or aggregates, or even as powders. Independently on the dosage form, the first necessary step for […]

Liposomes-based delivery systems

Liposomes-based delivery systems

Liposomes-based delivery systems – Definition and Release Mechanism Liposomes are carrier systems suitable for the delivery of different active molecules; due to their unic features, they can be utilized in many fields of application such as pharmaceutical, medical, nutraceutical, cosmeceutical. In medical field liposomes are used for the controlled delivery of drugs in order to […]

Polymeric micro and nano particles: definition and benefits

Polymeric micro and nano particles: definition and benefits

Polymeric micro and nano particles: definition and benefits Several compounds were incorporated in micro or nano carriers by different techniques, in order to stabilize them, convert them into powders, mask undesired taste, provide modified release properties. These systems are then exploited for therapeutic purposes to transport the active principle in a controlled manner from the […]

Wet granulation: importance and formation mechanisms of the granulates

Wet granulation: importance and formation mechanisms of the granulates

Wet granulation: importance and formation mechanisms of the granulates Nowadays, granulation products are largely used in pharmaceutical, food, cosmetic, agriculture, zootechnical industries and in the field of environmental remediation. Generally the use of granulates improves measure operations, volumetric dosage, storage, packing and transport of the materials. Why are granulates important? The granulation process allows to […]

Hydrogel-based delivery systems – Definition and Release Mechanism

Hydrogel-based delivery systems – Definition and Release Mechanism

Hydrogel-based delivery systems – Definition and Release Mechanism To explicate its therapeutic effect an Active Ingredient (AI) has to be available at a certain dose for a given time in a specific environment. To fulfill these requirements controlled delivery systems need to be properly designed, so that the drug can be released with desired release kinetics […]