Diego Caccavo

Diego Caccavo

Research Fellow

telephone +39.089.964077

mail dcaccavo@unisa.it

 

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Academic Curriculum

Diego Caccavo graduated, summa cum laude, in Chemical Engineering in the 2013 at the University of Salerno with a thesis in “Mathematical description of hydrogels’ behavior for biomedical applications”, partially developed at the Chalmers University of Technology (Sweden).

In the triennium 2014-2016 he has been student of the doctorate course in Industrial Engineering, Chemical Engineering curriculum, at DIIN of the University of Salerno, with a thesis in “Analysis and modeling of the behavior of hydrogels-based systems for biomedical and agro-food applications”.

During this period he has been coauthor of several publications on international scientific journals and of several international conference proceedings. His main research activities concern the analysis and modeling of hydrogel-based systems behavior for biomedical and agro-food applications. The engineering approach used to study these systems, based on the conservation laws of mass, momentum and energy, coupled to the FEM analysis, has permitted to develop mathematical tools able to describe the hydrogel-based systems behavior, therefore useful in their design phase. Other research activities are the production and characterization of controlled release fertilizers based on hydrogels, the modeling of drug release form core-shell polydisperse particulate systems, the characterization and modeling of gel-packs for isothermal box for the cold-chain applications. Moreover, in the 2015 he has collaborated, by means of a contract work at DIIN, to the project “Virtualizzation of heat transfer in meat substrates subjected to ohmic heating”, with the aim of developing a mathematical model of the process.

His didactic activities consisted in monographic seminars and collaborations in the frame of the courses of Chemical Engineering Principles (2014/2017) and Transport Phenomena in Food Processes (2014/2017) at DIIN. He took part as honorary fellow to the examination board in the years (2014/2016) of the courses Chemical Engineering Principles and Transport Phenomena in Food Processes. Moreover, he was co-advisor of 7 theses in Chemical Engineering, of which 4 B.Sc. and 3 M.Sc.

Theses

PhD thesis

  • Diego Caccavo, Analysis and modeling of the behavior of hydrogels-based systems for biomedical and agro-food applications, PhD in Industrial Engineering, Supervisor: Prof. Ing. Gaetano Lamberti, Scientific Committee: Prof.ssa Anna Angela Barba, Prof.ssa Anette Larsson (Chalmers University of Technology, Sweden), Prof. Juergen Siepmann (University of Lille, France), full thesis.

Master thesis

  • Diego Caccavo, Mathematical description of hydrogels’ behavior for biomedical applications, Laurea Magistrale in Ingegneria Chimica, student ID: 622200046, defence date: 11/11/13, supervisor(s): Prof. Ing. Gaetano Lamberti, Prof. Ing. Anette Larsson, assistant supervisor(s): Ing. Sara Cascone, thesis extract, full thesis
    (This thesis has been awarded with the prize in memory of Prof. Ing. Mario Maria Jacopetti, by Distretto 2100 of Rotary International, as the best thesis in industrial engineering in the year 2012/13)
    (This thesis has been awarded as one of the best 5 Italian Master theses in Chemical Engineering in the year 2013/14 by AIDIC-GRICU) link

Bachelor thesis

  • Diego Caccavo, Analisi del processo di granulazione per la produzione di forme farmaceutiche solide, Laurea in Ingegneria Chimica, student ID: 610200279, defence date: 22/02/11, supervisor(s): Prof. Ing. Gaetano Lamberti, assistant supervisor(s): Ing. Sara Cascone, thesis extract, full thesis

Publications

Show all

2019

Caccavo, Diego

An overview on the mathematical modeling of hydrogels’ behavior for drug delivery systems Journal Article

International Journal of Pharmaceutics, 560 , pp. 175-190, 2019.

Abstract | Links | BibTeX | Tags: Hydrogel Modeling

De Simone, Veronica ; Dalmoro, Annalisa; Lamberti, Gaetano; Caccavo, Diego; D'Amore, Matteo; Barba, Anna Angela

Effect of binder and load solubility properties on HPMC granules produced by wet granulation process Journal Article

Journal of Drug Delivery Science and Technology, 49 , pp. 513-520, 2019.

Abstract | Links | BibTeX | Tags: Granulation, HPMC

2018

De Simone, Veronica ; Caccavo, Diego; Lamberti, Gaetano; D'Amore, Matteo; Barba, Anna Angela

Wet-granulation process: phenomenological analysis and process parameters optimization Journal Article

Powder Technology, 340 , pp. 411-419, 2018.

Abstract | Links | BibTeX | Tags: Granulation, HPMC

De Simone, Veronica ; Caccavo, Diego; Dalmoro, Annalisa; Lamberti, Gaetano; D'Amore, Matteo; Barba, Anna Angela

Inside the Phenomenological Aspects of Wet Granulation: Role of Process Parameters Book Chapter

Kyzas, George (Ed.): Chapter 5, IntechOpen, 2018, ISBN: 978-1-78984-308-8.

Abstract | Links | BibTeX | Tags: Granulation, HPMC, Mathematical modeling

Caccavo, Diego; Vietri, Antonella; Lamberti, Gaetano; Barba, Anna Angela; Larsson, Anette

Modeling the mechanics and the transport phenomena in hydrogels Book Chapter

Manca, Davide (Ed.): Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Chapter 12, 2018.

Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela

Hydrogels: experimental characterization and mathematical modelling of their mechanical and diffusive behaviour Journal Article

Chemical Society Reviews, 47 (7), pp. 2357-2373, 2018, ISSN: 0306-0012.

Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling

De Simone, Veronica ; Dalmoro, Annalisa; Lamberti, Gaetano; Caccavo, Diego; D'Amore, Matteo; Barba, Anna Angela

HPMC granules by wet granulation process: Effect of vitamin load on physicochemical, mechanical and release properties Journal Article

Carbohydrate Polymers, 181 , pp. 939-947, 2018.

Abstract | Links | BibTeX | Tags: Granulation

2017

Caccavo, Diego; Barba, Anna Angela; D'Amore, Matteo; De Piano, Raffaella ; Lamberti, Gaetano; Rossi, Alessandra; Colombo, Paolo

Modeling the modified drug release from curved shape drug delivery systems - Dome Matrix® Journal Article

European Journal of Pharmaceutics and Biopharmaceutics, 121 , pp. 24-31, 2017, ISSN: 0939-6411.

Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling

Caccavo, Diego; Cascone, Sara; Apicella, Pietro; Lamberti, Gaetano; Barba, Anna Angela

HPMC-Based Granules for Prolonged Release of Phytostrengtheners in Agriculture Journal Article

Chemical Engineering Communications, 204 (12), pp. 1333-1340, 2017, ISSN: 0098-6445.

Abstract | Links | BibTeX | Tags: Granulation, HPMC

Caccavo, Diego; Lamberti, Gaetano; Barba, Anna Angela; Abrahmsén-Alami, Susanna; Viridén, Anna; Larsson, Anette

Effects of HPMC substituent pattern on water up-take, polymer and drug release: an experimental and modelling study Journal Article

International Journal of Pharmaceutics, 528 (1-2), pp. 705-713, 2017, ISSN: 0378-5173.

Abstract | Links | BibTeX | Tags: Erosion, HPMC, Hydrogel Characterization, Hydrogel Modeling, Mathematical modeling

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Dalmoro, Annalisa; Barba, Anna Angela

Modeling of the behavior of natural polysaccharides hydrogels for bio-pharma applications Journal Article

Natural Product Communications, 12 (6), pp. 867-871, 2017, ISSN: 1934-578X.

Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling, Hydrogels, Mathematical modeling, Modeling

Caccavo, Diego; Lamberti, Gaetano

PoroViscoElastic model to describe hydrogels' behavior Journal Article

Materials Science and Engineering: C, 76 , pp. 102–113, 2017.

Abstract | Links | BibTeX | Tags: Hydrogel Modeling

Caccavo, Diego; Cascone, Sara; Poto, Serena; Lamberti, Gaetano; Barba, Anna Angela

Mechanics and transport phenomena in agarose-based hydrogels studied by compression-relaxation tests Journal Article

Carbohydrate Polymers, 167 , pp. 136–144, 2017.

Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling

Barba, Anna Angela; Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Chiarappa, Gianluca; Abrami, Michela; Grassi, Gabriele; Grassi, Mario; Tomaiuolo, Giovanna; Guido, Stefano; Brucato, Valerio; Carfì Pavia, Francesco ; Ghersi, Giulio; La Carrubba, Vincenzo ; Abbiati, Roberto Andrea; Manca, Davide

Engineering approaches in siRNA delivery Journal Article

International Journal of Pharmaceutics, 525 (2), pp. 343–358, 2017.

Abstract | Links | BibTeX | Tags: Micro and Nano Vectors

Kazlauske, Jurgita; Cafaro, Maria Margherita; Caccavo, Diego; Marucci, Maria Grazia; Lamberti, Gaetano; Barba, Anna Angela; Larsson, Anette

Determination of the release mechanism of Theophylline from pellets coated with Surelease® − a water dispersion of Ethyl cellulose Journal Article

International Journal of Pharmaceutics, 528 (1-2), pp. 345-353, 2017, ISSN: 0378-5173.

Abstract | Links | BibTeX | Tags: Drug Delivery Systems, drug release, Hydrogel Characterization

Caccavo, Diego; Lamberti, Gaetano; Cafaro, Maria Margherita; Barba, Anna Angela; Kazlauske, Jurgita; Larsson, Anette

Mathematical modeling of the drug release from an ensemble of coated pellets Journal Article

British Journal of Pharmacology, 174 (12), pp. 1797–1809 , 2017, ISBN: 1476-5381.

Abstract | Links | BibTeX | Tags: Drug Delivery Systems, drug release, Hydrogel Characterization, Hydrogel Modeling

Chiarappa, Gianluca; Grassi, Mario; Abrami, Michela; Abbiati, Roberto Andrea; Barba, Anna Angela; Boisen, Anja; Brucato, Valerio; Ghersi, Giulio; Caccavo, Diego; Cascone, Sara; Caserta, Sergio; Elvassore, Nicola; Giomo, Monica; Guido, Stefano; Lamberti, Gaetano; Larobina, Domenico; Manca, Davide; Marizza, Paolo; Tomaiuolo, Giovanna; Grassi, Gabriele

Chemical Engineering in the “BIO” world Journal Article

Current Drug Delivery, 14 (2), pp. 158 - 178, 2017.

Abstract | Links | BibTeX | Tags:

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela; Larsson, Anette

Drug delivery from hydrogels: a general framework for the release modeling Journal Article

Current Drug Delivery, 14 (2), pp. 179 - 189, 2017.

Abstract | Links | BibTeX | Tags: Hydrogel Modeling

2016

Lamberti, Gaetano; Barba, Anna Angela; Cascone, Sara; Dalmoro, Annalisa; Caccavo, Diego

An Engineering Point of View on the Use of the Hydrogels for Pharmaceutical and Biomedical Applications Book Chapter

Majee, Sutapa Biswas (Ed.): Emerging Concepts in Analysis and Applications of Hydrogels, Chapter 8, Intech, 2016, ISBN: 978-953-51-2510-5.

Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela; Larsson, Anette

Swellable Hydrogel-based Systems for Controlled Drug Delivery Book Chapter

Sezer, Ali Demir (Ed.): Smart Drug Delivery System, Chapter 10, Intech, 2016, ISBN: 978-953-51-2247-0.

Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling

Caccavo, Diego; Ström, Anna; Larsson, Anette; Lamberti, Gaetano

Modeling capillary formation in calcium and copper alginate gels Journal Article

Materials Science and Engineering: C, 58 , pp. 442–449, 2016, ISSN: 09284931.

Abstract | Links | BibTeX | Tags: Alginate, Gel capillaries, Hydrogel Characterization, Hydrogel Modeling, Ionotropic gelation, Modeling

2015

Caccavo, Diego; Lamberti, Gaetano; Cascone, Sara; Barba, Anna Angela; Larsson, Anette

Understanding the adhesion phenomena in carbohydrate-hydrogel-based systems: Water up-take, swelling and elastic detachment Journal Article

Carbohydrate Polymers, 131 , pp. 41–49, 2015, ISSN: 01448617.

Abstract | Links | BibTeX | Tags: Bio-adhesion, Carbopol, Elastic behavior, Hydrogel Characterization, Hydrogel Modeling, Modeling, Water transport

Abrahmsén-Alami, Susanna; Caccavo, Diego; Lamberti, Gaetano; Barba, Anna Angela; Viridén, Anna; Larsson, Anette

Hydrogel-based drug delivery systems (HB-DDSs): a combined experimental-modeling approach Journal Article

AstraZeneca Internal Journal, pp. 1-2, 2015.

Abstract | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling

Caccavo, Diego; Cascone, Sara; Bochicchio, Sabrina; Lamberti, Gaetano; Dalmoro, Annalisa; Barba, Anna Angela

Hydrogels-based matrices behavior: experimental and modeling description Inproceedings

42nd Annual Meeting & Exposition of the Controlled Release Society, 2015.

BibTeX | Tags:

Caccavo, Diego; Apicella, Pietro; Cascone, Sara; Dalmoro, Annalisa; Lamberti, Gaetano; Barba, Anna Angela

Hydrogels-based systems for controlled release in agricultural applications Inproceedings

42nd Annual Meeting & Exposition of the Controlled Release Society, 2015.

BibTeX | Tags: Hydrogel Characterization

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela

Hydrogel-Based CRSs Analyses: Testing And Modeling Inproceedings

1st International Congress of Controlled Release Society - Greek Local Chapter, pp. 1–1, 1st International Congress of Controlled Release Society, Athens (Greece), 2015.

BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela

Controlled drug release from hydrogel-based matrices: Experiments and modeling. Journal Article

International journal of pharmaceutics, 486 (1-2), pp. 144–152, 2015, ISSN: 1873-3476.

Abstract | Links | BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling, Hydrogels, Modeling, Texture analysis, Transport phenomena, Water uptake

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela

Modeling the Drug Release from Hydrogel-Based Matrices Journal Article

Molecular Pharmaceutics, 12 (2), pp. 474–483, 2015, ISSN: 1543-8384.

Links | BibTeX | Tags: Hydrogel Modeling

Caccavo, Diego; Cascone, Sara; Amoroso, Maria Chiara; Apicella, Pietro; Lamberti, Gaetano; Barba, Anna Angela

Hydrogel-based Granular Phytostrengtheners for Prolonged Release: Production and Characterization Journal Article

Chemical Engineering Transaction, 44 , pp. 235–240, 2015.

Abstract | Links | BibTeX | Tags: Granulation, Hydrogel Characterization, Tecnagri

Cascone, Sara; Apicella, Pietro; Caccavo, Diego; Lamberti, Gaetano; Barba, Anna Angela

Optimization of Chelates Production Process for Agricultural Administration of Inorganic Micronutrients Journal Article

Chemical Engineering Transaction, 44 , pp. 217–222, 2015.

Abstract | Links | BibTeX | Tags: Chelating Agents, Tecnagri

2014

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela

Testing and modelling of hydrogels behavior for pharmaceutical and biomedical applications Inproceedings

Proceedings of CHISA 2014, pp. 1–1, CHISA 2014, Prague, Czech Republic, 2014.

BibTeX | Tags: Hydrogel Characterization, Hydrogel Modeling

Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; Barba, Anna Angela

In-vitro models of the gastro-intestinal tract for pharmaceutical and nutritional purposes Inproceedings

Proceedings of CHISA 2014/PRES 2014, pp. 2–2, CHISA 2014, Prague, Czech Republic, 2014.

BibTeX | Tags: In vitro, Pharmacokinetics

Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Titomanlio, Giuseppe; D'Amore, Matteo; Barba, Anna Angela

MODELING THE BEHAVIOR OF SWELLABLE HYDROGELS-BASED MATRICES FOR PHARMACEUTICAL APPLICATIONS Inproceedings

13th European Symposium on Controlled Drug Delivery, pp. 3–4, ESCDD 2014, Egmond aan Zee, The Netherlands, 2014.

BibTeX | Tags: Hydrogel Modeling

2013

Schuster, Erich; Caccavo, Diego; Eckardt, Johanna; Altskär, Annika; Hermansson, Anne-Marie; Larsson, Anette; Ström, Anna

Spontaneous formation of parallel aligned macropores within polysaccharide gels Inproceedings

Materials for Tomorrow, 2013.

Abstract | BibTeX | Tags: Alginate

Schuster, Erich; Caccavo, Diego; Eckardt, Johanna; Altskär, Annika; Hermansson, Anne-Marie; Larsson, Anette; Ström, Anna

Microstructural, mechanical and mass transport properties of alginate capillary gels Inproceedings

International Symposium on the Properties of Water, Fiskebäckskil, Sweden, 2013.

BibTeX | Tags: Alginate

2011

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano

Criteri per progettare e gestire il processo di granulazione Journal Article

ICP Rivista dell'Industria Chimica, 4 , pp. 74–78, 2011.

Abstract | BibTeX | Tags: Granulation