PRIN 2010-11

MIUR75PRIN 2010-11

(cod. 20109PLMH2)

Title

Identification of optimal delivery systems for the Nucleic Acid Based Drugs and study of the action mechanisms in some models of human tumoral and inflammatory pathologies

Principal Investigator: Mario Grassi

Abstract

For hepatocellular carcinoma, prostate adenocarcinoma, coronary restenosis, abdominal aortic aneurism, inflammatory bowel and lung diseases, a significant improvement in the efficacies of the therapeutic approaches so far available is urgently required. The use of “nucleic acid based drugs” (NABDs), a novel and emergent class of molecules, is considered very promising. However, a limitation in NABD use as drugs depends on the lack of optimal delivery systems able to minimize NABD degradation in the biological fluid and allow the targeting to the diseased tissue.
The aim of this project is to develop novel delivery systems for NABDs, appropriate for the considered human pathologies. Our approach will take into consideration the different problematics related to the engineering field, but also chemical, pharmaceutical and biomedical filed. Nine University groups will take part to the project together with eigtheen other non-University research groups.

Research units

UnitTeam managerActivities
01. UNITSMario GrassiRead More
02. UNISAGaetano Lamberti Read More
03. UNIPVPiersandro Pallavicini Read More
04. UNINAStefano Guido Read More
05. CNR NADomenico LarobinaRead More
06. UNIPA1Gennara CavallaroRead More
07. UNIPA2Valerio BrucatoRead More
08. UNIFGSante Di GioiaRead More
09. POLIMIDavide MancaRead More

 

Research products

Articles published on international journals

Read More

Conference Proceedings

Read More

Dissemination

I meeting 5-6 February 2013 – Trieste

Program:

primo-meeting-prin_pagina_1 primo-meeting-prin_pagina_2

Download the flier: I meeting PRIN

II meeting 27-29 September 2013  – Palermo

Program:

secondo-meeting-prin_pagina_1secondo-meeting-prin_pagina_2

Download the flier: II meeting PRIN

III meeting 20-21 June 2014 – Ustica

Program:

terzo-meeting-prin_pagina_1terzo-meeting-prin_pagina_2

Download the flier: III meeting PRIN

IV meeting 2-3 February 2015 – Milano

Program:

quarto-meeting-prin_pagina_1 quarto-meeting-prin_pagina_2

Download the flier: IV meeting PRIN

V meeting 14-15 September 2015 – Salerno

Go to the dedicated page: Workshop – New trends in gene therapy

Program:

quinto-meeting-prin_pagina_1quinto-meeting-prin_pagina_2

Download the flier: V meeting PRIN

VI meeting 24-25 May 2016 – Trieste

Flyer and program:

Locandina 5°Meetingsesto-meeting-prin_pagina_1sesto-meeting-prin_pagina_2

Download the flier: VI meeting PRIN